The 2025 Policy Note on Mainstreaming Gender Equality in Water Resources Management highlights the urgent need to integrate gender perspectives to achieve SDG 5 (gender equality) and SDG 6 (water and sanitation). It serves as a call to action for practitioners in water management and gender mainstreaming, highlighting key challenges and presenting seven powerful enablers for progress. The note showcases successful examples from various countries and emphasizes the importance of coordinated efforts to ensure sustainable and inclusive water management.