This CTCN Knowledge Brief illustrates the potential of nature-based solutions (NbS) to meet the diversity of critical needs that have been exacerbated by climate and COVID, bringing together more than 15 case studies from various countries and contexts across the region. It provides an illuminating and inspiring overview of the use of NbS technologies from which we can borrow as we move forward in adopting and implementing holistic solutions that exploit synergies wherever possible to tackle climate change and water management challenges in rural, urban and coastal areas.